This two-volume set, CCIS 2068 and 2069, constitutes selected papers presented during the Second Pan-African Conference on Artificial Intelligence, PanAfriCon AI 2023, held in Addis Ababa, Ethiopia, in October 2023. The set goal of the conference is to exchange the best practices of joint Pan-African efforts to provide solutions for Africa’s key 21st century challenges in the social, economic and ecologic domains. The 29 papers were thoroughly reviewed and selected from 134 submissions. The papers are organized in the following topical sections: Medical AI; Natural Language Processing, Text and Speech Processing; AI in Finance and Cyber Security; Autonomous Vehicles; AI Ethics and Life Sciences.