This volume constitutes the refereed proceedings of the Second International Conference on Computing, Communication and Learning, CoCoLe 2023, held in Warangal, India, in August 29–31, 2023. The 25 full papers presented were carefully reviewed and selected from 120 submissions. The CoCoLe conference focuses on Application of Supervised Learning in Computing; Application of Unsupervised Learning in Computing; and Computing in Communication Networks.