This book constitutes the refereed post-conference proceedings of the Second International Conference on Pan-African Intelligence and Smart Systems, PAAISS 2022, which was held in Dakar, Senegal, in November 2022. The 27 revised full papers presented were carefully selected from 70 submissions. The theme of PAAISS 2022 was: ?IoT and Enabling Smart System Technologies, Special Topics of African Interest, Artificial Intelligence Theory and Methods, Artificial Intelligence Applications in Medicine, Remote sensing and AI in Agriculture, AI applications and Smart Systems technologies, Affective Computing, Intelligent Transportation systems.