This book constitutes thoroughly refereed and revised selected papers from the proceedings of 19th European Conference on Multi-Agent Systems, EUMAS 2022, held in Düsseldorf, Germany, during September 14–16, 2022. The 23 full papers included in this book were carefully reviewed and selected from 36 submissions. The book also contains 6 short summaries of talks from PhD students at the PhD day. The papers deal with current topics in the research and development of multi-agent systems.