This book constitutes the proceedings of the 5th International Conference on Applied Informatics, ICAI 2022, which took place in Arequipa, Peru, in October 2022. The 32 papers presented in this volume were carefully reviewed and selected from 90 submissions. The contributions are divided into the following thematic blocks: Artificial Intelligence; Data Analysis; Decision Systems; Health Care Information Systems; ICT-Enabled Social Innovation; Image Processing; Robotic Autonomy; Software Architectures; Software Design Engineering.