This book constitutes the refereed proceedings of the 5th International Conference on Intelligence Science, ICIS 2022, held in Xi'an, China, in August 2022. The 41 full and 5 short papers presented in this book were carefully reviewed and selected from 85 submissions. They were organized in topical sections as follows: Brain cognition; machine learning; data intelligence; language cognition; remote sensing images; perceptual intelligence; wireless sensor; and medical artificial intelligence.