This book constitutes refereed proceedings of the 2nd International Conference on Computer and Communication Engineering, CCCE 2022, held in Rome, Italy, March 11–13, 2022. The 9 full papers and 8 short papers presented in this volume were carefully reviewed and selected from a total of 36 submissions. The papers in the volume are organised according to the following topical headings: information science and mobile communication; computer and electronic engineering.