This book constitutes the refereed proceedings of the 28th International Conference on Information and Software Technologies, ICIST 2022, held in Kaunas, Lithuania, in October 2022. The 23 full papers and 3 short papers presented were carefully reviewed and selected from 66 submissions. The papers discuss such topics as ?business intelligence for information and software systems, intelligent methods for data analysis and computer aided software engineering, information technology applications, smart e-learning technologies and applications, language technologies.