This book constitutes the proceedings of the 30th International Conference on Case-Based Reasoning, ICCBR 2022, which took place in Nancy, France, during September 12-15, 2022. The theme of ICCBR 2022 was Global Challenges for CBR aiming to consider how CBR can and might contribute to challenges in sustainability, climate change, and global health. The 26 papers presented in this volume were carefully reviewed and selected from 68 submissions. They deal with AI and related research focusing on comparison and integration of CBR with other AI methods such as deep learning architectures, reinforcement learning, lifelong learning, and eXplainable AI (XAI).