This book constitutes the refereed proceedings of the 22nd International Conference on Runtime Verification, RV 2022, held in Tbilisi, Georgia, during September 28-30, 2022. The 12 regular papers and 10 short papers presented in this book were carefully reviewed and selected from 40 submissions. The RV conference is concerned with all aspects of monitoring and analysis of hardware, software and more general system executions. Runtime verification techniques are crucial for system correctness, reliability, and robustness; they provide an additional level of rigor and effectiveness compared to conventional testing, and are generally more practical than exhaustive formal verification.