This book constitutes the proceedings of the 5th International Workshop on Predictive Intelligence in Medicine, PRIME 2022, held in conjunction with MICCAI 2022 as a hybrid event in Singapore, in September 2022. The 19 papers presented in this volume were carefully reviewed and selected for inclusion in this book. The contributions describe new cutting-edge predictive models and methods that solve challenging problems in the medical field for a high-precision predictive medicine.