This book constitutes the refereed proceedings of the 4th International Conference on HCI for Cybersecurity, Privacy and Trust, HCI-CPT 2022, held as part of the 23rd International Conference, HCI International 2022, which was held virtually in June/July 2022. The total of 1271 papers and 275 posters included in the HCII 2022 proceedings was carefully reviewed and selected from 5487 submissions. The HCI-CPT 2022 proceedings focuses on to user privacy and data protection, trustworthiness and User Experience in cybersecurity, multi-faceted authentication methods and tools, HCI in cyber defense and protection, studies on usable security in Intelligent Environments, as well as the impact of the Covid-19 pandemic on cybersecurity