This book constitutes the proceedings of the 16th International Conference on Algorithms and Computation, WALCOM 2022, which was held in Jember, Indonesia, during March 24-26, 2022. This proceedings volume contains 30 full papers which were carefully reviewed and selected from a total of 89 submissions and 3 invited papers. They cover diverse areas of algorithms and computation, such as approximation algorithms, computational complexity, computational geometry, graph algorithms, graph drawing and visualization, online algorithms, parameterized complexity and property testing.