This book constitutes the refereed proceedings of the 14th International Conference on Artificial General Intelligence, AGI 2021, held as a hybrid event in San Francisco, CA, USA, in October 2021. The 36 full papers presented in this book were carefully reviewed and selected from 50 submissions. The papers cover topics from foundations of AGI, to AGI approaches and AGI ethics, to the roles of systems biology, goal generation, and learning systems, and so much more.