This book constitutes the refereed proceedings of the 18th International Conference on Mobile Web and Intelligent Information Systems, MobiWIS 2022, held in Rome, Italy, in August 2022. The 18 full papers and 1 short paper presented in this book were carefully reviewed and selected from 51 submissions. The papers of MobiWIS 2022 deal focus on topics such as security and privacy; web and mobile applications; networking and communication; intelligent information systems; and IoT and ubiquitous computing.