This book is the first comThis three-volume set constitutes the refereed proceedings of the 14th International Conference on Knowledge Science, Engineering and Management, KSEM 2021, held in Tokyo, Japan, in August 2021. The 164 revised full papers were carefully reviewed and selected from 492 submissions. The contributions are organized in the following topical sections: knowledge science with learning and AI; knowledge engineering research and applications; knowledge management with optimization and security.