This book constitutes the refereed post-conference proceedings of the 7th International Conference on Nature of Computation and Communication, ICTCC 2021, held in October 2021. Due to COVID-19 pandemic the conference was held virtually. The 17 revised full papers presented were carefully selected from 43 submissions. The papers of ICTCC 2021 cover formal methods for self-adaptive systems and discuss natural approaches and techniques for natural computing systems and their applications.