This book constitutes the revised selected papers of the 5th International Conference on Information Systems Security and Privacy, ICISSP 2019, held in Prague, Czech Republic, in February 2019. The 19 full papers presented were carefully reviewed and selected from a total of 100 submissions. The papers presented in this volume address various topical research, including new approaches for attack modelling andprevention, incident management and response, and user authentication andaccess control, as well as business and human-oriented aspects such as data pro-tection and privacy, and security awareness.