This book constitutes the refereed proceedings of the 22nd International Symposium on Stabilization, Safety, and Security of Distributed Systems, SSS 2020, held in Austin, TX, USA, in November 2020. The 16 full papers, 7 short and 2 invited papers presented were carefully reviewed and selected from 44 submissions. The papers deal with the design and development of distributed systems with a focus on systems that are able to provide guarantees on their structure, performance, and/or security in the face of an adverse operational environment.