This book constitutes the proceedings of the 4th International Conference on e-Learning, e-Education, and Online Training, e-LEOT 2018, held in Shanghai, China, in April 2018. The 49 revised full papers presented were carefully reviewed and selected from 120 submissions. They focus on the most recent and innovative trends in this broad area, ranging from distance education to collaborative learning, from interactive learning environments to the modeling of STEM (Science, Technology, Mathematics, Engineering) curricula.