This book constitutes revised selected papers from the 15th International Conference on Informatics in Economy, IE 2016, held in Cluj-Napoca, Romania, in June 2016. The 10 full papers and 4 short papers presented in this volume were carefully reviewed and selected from 31 extended paper submissions for this book. They are organized in sections on Distributed Systems, Information Systems Adoption, Knowledge Representation, and Processing, Domain-specific Data Analysis, and Computational Models. The volume also contains one invited keynote paper in full-paper length.