In holistic Digital Humanities studies of information infrastructure, we cannot rely solely on the selection of any given techniques from various disciplines. In addition to selecting our research methods pragmatically, for their relative efficacy at answering a part of a research question, we must also attend to the way in which those methods complement or contradict one another. In my study on West African network backbone infrastructure, I use the tools of different humanities, social-sciences, and computer science disciplines depending not only on the type of information that they help glean, but also on how they can build upon one another as I move through the phases of the study. Just as the architecture of information infrastructure includes discrete “layers” of machines, processes, human activity, and concepts, so too does the study of that architecture allow for multiple layers of abstraction and assumption, each a useful part of a unified, interdisciplinary approach.