This book constitutes the proceedings of the 18th International Conference on Cooperative Design, Visualization, and Engineering, CDVE 2021, held in October 2021. Due to COVId-19 pandemic the conference was held virtually. The 25 full papers and 9 short papers presented were carefully reviewed and selected from 69 submissions. The achievement, progress and future challenges are reported in areas such as health care, industrial design, banking IT systems, cultural activities support, operational maritime cybersecurity assurance, emotion communication, and social network data analytics.