This book constitutes the proceedings of the 19th International Conference on Web Information Systems and Applications, WISA 2022, held in Dalian, China, in September 2022. The 45 full papers and 19 short papers presented were carefully reviewed and selected from 212 submissions. The papers are grouped in topical sections on knowledge graph, natural language processing, world wide web, machine learning, query processing and algorithm, recommendation, data privacy and security, and blockchain.